Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
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Clozaril Product Description
Drug Uses
Clozaril is an atypical antipsychotic agent, providing sedative, antipsychotic, antihistamine and anticholinergic effects. Clozaril is indicated to teenagers aged 18 years and above, adults and elderly patients for treatment of:
treatment-resistant schizophrenia
psychosis during the course of Parkinson's disease
suicidal behavior in patients with schizophrenia or schizoaffective disorder
Clozaril benefits are that the drug does not virtually cause any extrapyramidal side effects such as akathisia, dystonia, bradykinesia and tremor, like other antypsyshotics do.
In contrast to classic antipsychotics, Clozaril does not increase at all or insignificantly increases the level of prolactin. Because of this, such side effects as galactorrhea, gynaecomastia and amenorrhea are normally avoided during the antipsychotic treatment with Clozaril.
To treat mental disorders, a therapeutic dose of Clozaril is recommended to be adjusted individually. At the beginning of antipsychotic therapy, low doses of Clozaril are most effective ones. For the treatment of severe mental diseases, the maximum daily Clozaril dose of 900mg can be indicated. But Clozaril doses above 450mg may significantly increase the risk of seizures and other side effects.
Missed dose
Under no circumstances should the prescribed dose of Clozaril be increased or decreased. It is stricktly not recommended to interrupt Clozaril application for more than 2 days. If you’ve forgotten to take Clozaril tablets, take the missed dose of this antipsychotic drug as soon as you remember. However, if it is nearly the time for the next prescribed dose, do not take an extra antipsychotic pill to make up the missed dose of Clozaril.
More Information
Sudden cessation of the intake of the antypsyshotic drug may cause withdrawal symptom and adverse reactions. If treatment is required to be immediately terminated (for example, in case of developing eosinophilia), gradual reduction of Clozaril dose and careful observance for the patient's mental state are recommended. Patients 60 year old and above should start the antipsychotic treatment with very low doses of Clozaril, and gradually increase the daily dose, not more than by 25mg per day.
Storage
Store the Clozaril tablets in an original container to protect them from heat and moisture. Keep Clozaril out of the reach of children at temperature not above 30°C.
Clozaril Safety Information
Warnings
During the treatment with Clozaril, severe neutropenia (abnormally low count of neutrophils) may develop in some patients, resulting in complex infection. High risk of neutropenia is observed in the first days of the antipsychotic therapy, and then is gradually decreased. Clozaril may increase the risk of seizures, so epileptic patients should take the antipsychotic with caution.
Disclaimer
Information about psychotic diseases, contained in the review of Clozaril, is
provided for the informational purposes only and should not be considered to
substitute for qualified medical care or advice of the health care provider.
The online pharmacy does not assume any liability or responsibility for damage,
arising from any use of information on atypical antipsychotic agent Clozaril.
Clozaril Side Effects
Most adverse effects of Clozaril appear only at the beginning of the antipsychotic therapy and eventually disappear. The most frequent and serious adverse effects, which Clozaril may cause include: leukocytopenia, somnolence, dizziness and psychotic disorder. Other common adverse effects of antipsychotic agent Clozaril are reported as: granulopenia, seizure triggers, cardiovascular effects, fever drowsiness/sedation, dizziness, tachyarrhythmia, constipation and ptyalism.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
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Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
Colospa - myotropic spasmolytic with selective effect on unstriated muscles of digestive tract. Eliminates a spasm, without influencing a normal peristaltics of intestines. Unlike cholinolytic medicine, Colospa does not affect at muscarinic receptor and does not cause characteristic of antispasmodics with muscarinic receptor action of side effects (feeling of dryness in a mouth, vision disorders, an urination delay) that allows for patients to take it at prostatauxe or glaucoma. Taking of Colospa is not followed by development of reflex hypotonia of intestines.
Cozaar is used to treat arterial hypertension, protect the kidneys in type 2 diabetes mellitus with proteinuria, reduce the risk of associated cardiovascular diseases, as well as lower the death rate for hypertension, hypertrophy.
Desyrel antidepressive medicine, a derivative of thiazolopyridine; renders thymoleptic, anxiolytic, sedative and myorelaxation action. It is prescribed for treatment of various forms of depression (endogenous, psychotic, neurotic, somatogenic) including with the expressed state anxiety.
Endep - tricyclic antidepressant. The mechanism of antidepressive action is connected with increase in concentration of noradrenaline in synapses and/or serotonin in CNS (decrease in return absorption). Accumulation of these neurotransmitters results from inhibition of their return capture by membranes of presynaptic neurons.
Famvir - antiviral medicine which is taken for prevention and treatment of herpes at primary infection, post-herpetic neuralgia, recurrent genital herpes. Pro-medicine; represents a 6-deoxysidiacetil analog of active antiviral agent of a penciclovir.
Thiol derivative, a competitive hypoxanthine antagonist, has an immunosuppressive and cytostatic effect. It is used for prevention of rejection reaction in kidney transplantation, treatment of rheumatoid arthritis, chronic active hepatitis, SLE, dermatomyositis, periarteritis nodosa, acquired hemolytic anemia, gangrenous pyoderma, psoriasis, Crohn's disease, ulcerative colitis and myopathy.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
Pamelor is a tricyclic antidepressant (TCA, tricyclic antidepressants) of the second generation. It is used in the treatment of some major depressive disorder and nocturnal enuresis (bedwetting) in children. In addition, the drug is sometimes used for the treatment of chronic diseases such as chronic fatigue syndrome, chronic pain and migraine, and the lability in certain neurological diseases.
Tricor - is a hypolipidemic agent, has an uricosuric and antiplatelet effect. In combination with diet therapy, the drug is prescribed for a long-term treatment, the effectiveness of which must be periodically checked by determining serum lipid levels.
Vermox - anthelminthic drug of a wide spectrum of action. The most effective for Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni.
Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.
The effect of clomipramine is to inhibit the opposite neurological catching of serotonin and noradrenaline. The most crucial is the suppression of serotonin recapture. In addition, the medicine has a broad range of other pharmacological actions: alpha 1-adrenoliticheskoe, anticholinergic, antigestagen and antiserotonergic. The pill acts on the depressive disorder in general. The difference is usually observed after 2-3 weeks of therapy. Acticine also has a specific influence on obsessive-compulsive disorders.
Forxiga is the drug produced in the form of tablets. Tablets belong to SGLT2 inhibitors. Its main purpose is to reduce the level of blood sugar. It helps the kidney to remove glucose from the organism and excrete it during urination. It also helps to lose weight. Patients use the tablets to treat type II diabetes and get rid of the additional weight that is the result of the health disorder. The drug can be taken alone as a monotherapy or as an additional treatment. It doesn’t fit people with diabetes I.
It is a powerful tool which lowers cholesterol in the blood, strengthens blood vessels and fights parasites. Lasuna balances coronary function prevents the accumulation of cholesterol on the walls of the coronary arteries. The medicine stabilizes blood pressure levels. It regulates the level of lipids in plasma, the number of platelets in the blood, cholesterol and blood sugar and strengthens immunity. Strong antioxidant properties eliminate free radicals that cause an imbalance in the normal functioning of blood vessels, which should fully narrow and expand for their natural work.
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ERYC capsules contain enteric-coated pellets of erythromycin base for oral administration.
Erythromycin is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: