Trazodone is an antidepressant, a thiazolopyridine derivative. It also has a timoleptic, anxiolytic, sedative and miorelaxing action. Has a high affinity for some subtypes of serotonin receptors, inhibits the reuptake of serotonin; The neuronal capture of norepinephrine and dopamine affects little.
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Product Description
Trazodone is an antidepressant, which has a timoleptic, that is, mood-enhancing action, simultaneously combined with an anxiolytic and tranquilizing (anti-anxiety and soothing) effect. Applied with different forms of depression (suppressed states / endogenous, psychotic, neurotic, somatogenic, etc.), proceeding with anxiety, tension. Due to the good tolerability and lack of anticholinergic action, trazodone is widely used in the treatment of elderly patients with organic diseases of the central nervous system, as well as in the complex treatment of patients with somatic diseases (internal diseases) complicated by mental disorders (anxiety, tension, etc.).
Safety information
The initial dose for ingestion is 50 mg 3 times a day, then depending on the type and severity of depression may be increased up to 300-500 mg per day. Therapeutic effect is usually observed within 3-7 days from the beginning of treatment.
The drug should not be administered simultaneously with MAO inhibitors.
Trazodone is not indicated for pregnant women.
In case of the treatment by Trazodone the breastfeeding period should be stopped. Trazodone and its metabolites are found in the milk of lactating rats. It is not known whether trazodone is secreted into human milk in human milk.
Side effects
- fatigue, weakness, headache, dizziness, insomnia, drowsiness, agitation, psychosis, hypomania, hallucinations, tremor, muscle twitches, large convulsive seizures (grand mal), aphasia, ataxia, akathisia, dyskinesia, paresthesia, confusion, syncopal conditions , blurred vision, diplopia;
- arterial hypotension, incl. Orthostatic; Atrial fibrillation, arrhythmias, congestive heart failure, leukocytosis or leukopenia, neutropenia, hemolytic anemia, methemoglobinemia;
- increased appetite, dryness and unpleasant taste in the mouth, hypersalivation, caries, diseases of the peri-toothed tissues, candidiasis of the oral cavity, nausea, vomiting, flatulence, diarrhea, constipation, cholestasis, increased bilirubin and amylase in the blood plasma, jaundice;
- urinary retention, increased urination, hematuria, premature menstruation, hirsutism, increased libido, priapism, impotence, retrograde ejaculation;
- skin rash, hives;
- myalgia, pain in the chest, alopecia, psoriasis, swelling.
Being a part of the medicine Allegra - fexofenadine it is an antihistamine with a selective antagonistic activity to H1-receptors without anticholinergic and blocking alfa1-adrenergic receptors; also at fexofenadine isn't observed a sedative action and other effects from the central nervous system. The antihistaminic effect of Allegra is observed in 1 hour, reaching its maximum in 6 hours, and proceeds within 24 hours. After 28 days of taking the medicine there wasn't observed the accustoming to it.
Brand Levitra – a drug from Bayer, with a basic chemical called Vardenafil, is an improved remedy for treating erectile difficulties. Operates approximately within 6-8 hours, so a man may be ready to perform sexually the whole night.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
Cozaar is used to treat arterial hypertension, protect the kidneys in type 2 diabetes mellitus with proteinuria, reduce the risk of associated cardiovascular diseases, as well as lower the death rate for hypertension, hypertrophy.
Ditropan - the antispasmodic, eliminates spasms and lowers a tone of unstriated muscles: GIT, biliary tract, uterus, debilitates detruzor. Increases bladder capacity, reduces the frequency of reductions of a detruzor, constrains desires to urination. It is well tolerated by patients at long prescription. It is taken at a neurogenic bladder, an urine incontience, night enuresis at children.
Endep - tricyclic antidepressant. The mechanism of antidepressive action is connected with increase in concentration of noradrenaline in synapses and/or serotonin in CNS (decrease in return absorption). Accumulation of these neurotransmitters results from inhibition of their return capture by membranes of presynaptic neurons.
Eulexin - antineoplastic medicine, anti-androgen. Competitively blocks interaction of androgens with their cellular receptors; interferes with manifestation of biological effects of male sex hormones in androgensensetive organs. It is taken for palliative treatment of cancer.
Famvir - antiviral medicine which is taken for prevention and treatment of herpes at primary infection, post-herpetic neuralgia, recurrent genital herpes. Pro-medicine; represents a 6-deoxysidiacetil analog of active antiviral agent of a penciclovir.
Keflex – It is used for the treatment of infections of the upper respiratory tract, urogenital system, ENT organs, skin and soft tissues, bones and joints. Refers to a group of cephalosporin antibiotics of the first generation. It has an bactericidal effect, disrupts the synthesis of the cell wall of microorganisms. It is resistant enough to penicillinases of gram-positive microorganisms, It can be destroyed by beta-lactamases of gram-negative microorganisms.
An antidepressant used in cases of deep depression, panic disorders, social anxiety disorders, anxiety disorders. The mechanism of its action is based on the ability to selectively block the reuptake of serotonin by the presynaptic membrane of the neurons of the brain. Consequently, its serotonergic effect in the central nervous system that is responsible for the development of antidepressant effect, increases, which determines the effectiveness in the treatment of panic and social anxiety disorder.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
A blocker of H1-histamine receptors of the first generation, derived from ethanolamine; eliminates the effects of histamine, mediated through this type of receptors. Promotes the local anaesthesia (when intaken, there is a short numbing of the mucous membranes in the mouth) - only in high doses, it blocks m-cholinergic receptors in the central nervous system, has sedative, hypnotic, antiemetic and antiparkinsonian effects. The therapeutic indications include: allergic conjunctivitis, allergic rhinitis, chronic urticaria, pruritic dermatoses, dermatographism, serum sickness.
The drug is a prodrug and is activated in the acidic environment of the secretory tubules in the parietal cells. It reduces basal and stimulated secretion regardless of the nature of the stimulus. Prescribed in case of erosive ulcerative diseases of the gastrointestinal tract and eradication of Helicobacter pylori in infected patients with gastric and duodenal ulcer.
Prograf The active ingredient of the drug (Tacrolimus) binds to cytosolic protein (FKBP12), responsible for the intracellular accumulation of the drug. Designed for the prevention and treatment of allograft liver, kidneys and heart rejection reactions, including those resistant to standard immunosuppressive therapy regimes.
Vantin - combined preparation, based simultaneously on 2 active substances: Cefpodoxime Proxetil. It belongs to the third generation of cephalosporins. Used to treat acute otitis media, tonsilitis, pharyngitis, respiratory tract infections, such as pulmonary pneumonia and chronic bronchitis.
Zestril is an angiotensin-converting enzyme inhibitor (ACE). It works by relaxing the blood vessels. This helps lower blood pressure. It is used in the treatment of high blood pressure, alone or in conjunction with other medicines.
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
Careprost is designed for those who suffer from Hypotrichosis - it is a disease in which there is an insufficient growth of eyelashes. The drug stimulates the growth of eyelashes and makes them longer, thicker and darker. The result will be noticeable within a few weeks after the start of use. For maximum results, it will take 2 to 4 months of daily use. To maintain the effect, you need to apply the product 1-2 times a week. If you do not continue applying, the eyelashes will return to their original state after 1-2 months.
Sildenafil (ABHIGRA) 100 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
ERYC capsules contain enteric-coated pellets of erythromycin base for oral administration.
Erythromycin is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: