Glucophage - guanyl guanidine, hypoglycemic medicine for peroral takein. At patients with a diabetes mellitus reduces concentration of glucose in blood by oppression of gluconeogenesis in a liver, reduction of absorption of glucose from GIT and increase of its utilization in tissues. Stabilizes or reduces a body weight.
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Glucophage Product Description
Drug Uses
Glucophage is a hypoglycemic drug for oral use, belonging to the group of biguanides. Glucophage is used in the management of type 2 diabetes in pediatric overweight patients aged 10 years and older, and in overweight or obese adults.
Glucophage is prescribed to diabetic patients as an adjunct, when diet and physical activity are unable to regulate blood glucose level. This antihyperglycemic drug reduces glucose production by the liver and its intestinal absorption.
Clinical studies have shown that maintenance of normal blood glucose levels reduces the risk of diabetic complications (such as vision loss or eye disease, cardiovascular diseases). The recommended starting dose of Glucophage for adults is 850 to 1000 mg per day. The maximum daily dose should not exceed 2000mg of the antihyperglycemic drug.
Due to the reduction of renal activity in elderly patients and high risk of lactic acidosis, use of Glucophage should start with small doses of this antihyperglycemic drug, and titration should be made with caution. The initial daily dose of Glucophage for children is 500 mg in the morning and in the evening, with a maximum dose of 2000 mg.
Missed Dose
If you remember that you have missed a dose of Glucophage, take it with food as soon as you can, except when the time is approaching for taking the next dose of the oral antihyperglycemic agent. Then you should just skip one Glucophage dose, without doubling the following.
More Information
Glucophage hypoglycemic drug may be administered in combination with insulin or with other oral antidiabetic agents for the treatment of diabetes in obese adults. Glucophage is recommended as monotherapy or in combination with insulin for the treatment of obese children and adolescents. The patient is recommended to stop taking the antihyperglycemic drug Glucophage in the first symptoms of lactic acidosis (upset stomach, low blood pressure, slow heartbeat).
Storage
To protect the tablets from moisture and light, it is recommended to store Glucophage in an original light-resistant container. The optimum storage temperature for Glucophage tablets ranges from 20°C to 25°C.
Glucophage Safety Information
Warnings
It is recommended to stop taking Glucophage, if an intercurrent disease (congestive heart failure, hepatic dysfunction, or myocardial infarction) is observed in patient during the antihyperglycemic therapy. Prolonged use and high doses of the antihyperglycemic drug Glucophage may cause a violation of vitamin B12 absorption and lead to diseases, caused by lack of this vitamin in the body. To avoid them, measurement of hematologic parameters and prevention of subnormal vitamin B12 levels are recommended during the treatment.
Disclaimer
All information on hyperglycemia, provided in the review on Glucophage, is for information purposes only and can not be viewed as a substitute for professional advice of a health care specialist. We disclaim all liability for loss, claims and damages, resulting from improper use of materials on oral antihyperglycemic agent Glucophage.
Glucophage Side Effects
During the research test, conducted in the United States, the adverse reactions, registered in treatment with Glucophage, have been reported by more than 5% of patients. In the treatment with Glucophage, children of 10 years and above have the same adverse effects, as adults.
The most common adverse reactions manifest in the beginning of therapy with Glucophage. These include gastrointestinal disorders, like vomiting, diarrhea, loss of appetite and nausea. Some frequent adverse reactions, seen in the treatment with Glucophage, manifest after the drug use is discontinued. Such adverse reactions include abdominal pain, dyspepsia, abdominal distention, flatulence.
Glucophage may also cause other, less frequent, adverse reactions, like dyspnea, chills, hypoglycemia, taste disorder, flushing, myalgia, nail disorder, chest discomfort, palpitation, abnormal stools, rash, and taste disturbance.
Being a part of the medicine Allegra - fexofenadine it is an antihistamine with a selective antagonistic activity to H1-receptors without anticholinergic and blocking alfa1-adrenergic receptors; also at fexofenadine isn't observed a sedative action and other effects from the central nervous system. The antihistaminic effect of Allegra is observed in 1 hour, reaching its maximum in 6 hours, and proceeds within 24 hours. After 28 days of taking the medicine there wasn't observed the accustoming to it.
Brand Levitra – a drug from Bayer, with a basic chemical called Vardenafil, is an improved remedy for treating erectile difficulties. Operates approximately within 6-8 hours, so a man may be ready to perform sexually the whole night.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
Ampicillin - Semi-synthetic penicillin, which has a wide range of effects and exhibits bactericidal effect. Suppresses the synthesis of the cell wall of bacteria: Streptococcus pneumoniae, Staphylococcus spp., Bacillus anthracis, Clostridium spp., Enterococcus faecalis, Listeria spp., Haemophilus influenzae, Neisseria meningitidis, Proteus mirabilis, Pasteurella multocida, Salmonella spp., Shigella spp., Escherichia coli, Aerobic non-spore-forming bacteria. Acid-resistant.
Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
Cozaar is used to treat arterial hypertension, protect the kidneys in type 2 diabetes mellitus with proteinuria, reduce the risk of associated cardiovascular diseases, as well as lower the death rate for hypertension, hypertrophy.
Diltiazem - has anti-anginal, antiarrhytmic and hypotensive effects. Reduces the intracellular maintenance of Ca2+ in cardiomyocytes and cells of smooth muscles of blood vessels, reduces heart rate, shows insignificant negative inotropic effect, improves a coronary, brain and renal blood flow.
Ditropan - the antispasmodic, eliminates spasms and lowers a tone of unstriated muscles: GIT, biliary tract, uterus, debilitates detruzor. Increases bladder capacity, reduces the frequency of reductions of a detruzor, constrains desires to urination. It is well tolerated by patients at long prescription. It is taken at a neurogenic bladder, an urine incontience, night enuresis at children.
Endep - tricyclic antidepressant. The mechanism of antidepressive action is connected with increase in concentration of noradrenaline in synapses and/or serotonin in CNS (decrease in return absorption). Accumulation of these neurotransmitters results from inhibition of their return capture by membranes of presynaptic neurons.
Eulexin - antineoplastic medicine, anti-androgen. Competitively blocks interaction of androgens with their cellular receptors; interferes with manifestation of biological effects of male sex hormones in androgensensetive organs. It is taken for palliative treatment of cancer.
Famvir - antiviral medicine which is taken for prevention and treatment of herpes at primary infection, post-herpetic neuralgia, recurrent genital herpes. Pro-medicine; represents a 6-deoxysidiacetil analog of active antiviral agent of a penciclovir.
Keflex – It is used for the treatment of infections of the upper respiratory tract, urogenital system, ENT organs, skin and soft tissues, bones and joints. Refers to a group of cephalosporin antibiotics of the first generation. It has an bactericidal effect, disrupts the synthesis of the cell wall of microorganisms. It is resistant enough to penicillinases of gram-positive microorganisms, It can be destroyed by beta-lactamases of gram-negative microorganisms.
An antidepressant used in cases of deep depression, panic disorders, social anxiety disorders, anxiety disorders. The mechanism of its action is based on the ability to selectively block the reuptake of serotonin by the presynaptic membrane of the neurons of the brain. Consequently, its serotonergic effect in the central nervous system that is responsible for the development of antidepressant effect, increases, which determines the effectiveness in the treatment of panic and social anxiety disorder.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
A blocker of H1-histamine receptors of the first generation, derived from ethanolamine; eliminates the effects of histamine, mediated through this type of receptors. Promotes the local anaesthesia (when intaken, there is a short numbing of the mucous membranes in the mouth) - only in high doses, it blocks m-cholinergic receptors in the central nervous system, has sedative, hypnotic, antiemetic and antiparkinsonian effects. The therapeutic indications include: allergic conjunctivitis, allergic rhinitis, chronic urticaria, pruritic dermatoses, dermatographism, serum sickness.
Prograf The active ingredient of the drug (Tacrolimus) binds to cytosolic protein (FKBP12), responsible for the intracellular accumulation of the drug. Designed for the prevention and treatment of allograft liver, kidneys and heart rejection reactions, including those resistant to standard immunosuppressive therapy regimes.
Seroquel - treats acute and chronic psychoses, including schizophrenia. The drug is also prescribed to patients with manic episodes associated with bipolar disorders.
Vantin - combined preparation, based simultaneously on 2 active substances: Cefpodoxime Proxetil. It belongs to the third generation of cephalosporins. Used to treat acute otitis media, tonsilitis, pharyngitis, respiratory tract infections, such as pulmonary pneumonia and chronic bronchitis.
Zestril is an angiotensin-converting enzyme inhibitor (ACE). It works by relaxing the blood vessels. This helps lower blood pressure. It is used in the treatment of high blood pressure, alone or in conjunction with other medicines.
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
Sildenafil (ABHIGRA) 100 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
ERYC capsules contain enteric-coated pellets of erythromycin base for oral administration.
Erythromycin is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: