Indinavir is used to treat diseases caused by HIV-1 in adult patients who have not received antiretroviral therapy before or who have received antiretroviral drugs and who have contraindications or resistance to drugs - reverse transcriptase inhibitors.
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Product Description
Indinavir is a medicine that is used for antiretroviral therapy (ART). This type of medicine stops the reproduction of HIV by inhibiting the work of the enzyme reverse transcriptase. Indinavir is a protease inhibitor. The HIV protease works like a chemical scissors. It divides the HIV source material into parts necessary to build a new virus. Protease inhibitors stop the work of these "scissors".
Safety information
Indications and usage
Diseases caused by HIV-1 in adults:
- Previously untreated antiretroviral drugs (in combination with antiretroviral drugs or in the form of monotherapy at the beginning of treatment for patients who are clinically unsuitable for the appointment of nucleoside analogues);
- Previously antiretroviral drugs and having contraindications or resistance to drugs - reverse transcriptase inhibitors (in combination with antiretroviral drugs or as monotherapy).
Mode of application
Intake, 1 hour before or 2 hours after eating, squeezed with water - 800 mg every 8 hours. The initial dose - 2.4 g/day.
With simultaneous use with rifabutin dose reduced by 2 times; it appoints with ketoconazole of 600 mg every 8 hours.
With hepatic insufficiency, cirrhosis, nephrourolythiasis - 600 mg every 8 hours.
Contraindications
Hypersensitivity, pregnancy, lactation.
Indinavir should be used with caution by patients with hemophilia, hepatic failure, children and old age (safety and efficacy is not established).
Side effects
- Asthenia, dizziness, headache, hypoesthesia, sleep disorders (drowsiness), nervousness, depression, paresthesia, tremor, peripheral polyneuropathy.
- Arthralgia, myalgia, muscle cramps, rigidity of limb muscles, chest pain.
- Cough, breathing disorder, sinusitis, upper respiratory infections, pneumonia.
- Dysuria, nocturia, nefrourolitiaz, kidney pain, hematuria, proteinuria, hypercreatininaemia.
- Dry skin, itching, dermatitis.
- Spontaneous bleeding in patients with hemophilia A and B.
- Lymphadenopathy, fever, increased sweating, flu-like syndrome, hemolytic anemia.
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Zantac - ranitidin - the drug is intended for the treatment of duodenal ulcers, benign gastric ulcer, postoperative ulcer, reflux esophagitis, Zollinger-Ellison syndrome, epigastric or chest pain. The administration of ranitidine is indicated in cases where a decrease in gastric secretion and a decrease in the production of hydrochloric acid is desirable, for the prevention of gastrointestinal bleeding, for the prevention of recurrence of bleeding in patients with bleeding ulcers of the stomach and duodenum, before general anesthesia in patients with a presumed risk of aspiration of acidic stomach contents (Mendelssohn syndrome), especially in women during childbirth delivery clashes.
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