Zestril is an angiotensin-converting enzyme inhibitor (ACE). It works by relaxing the blood vessels. This helps lower blood pressure. It is used in the treatment of high blood pressure, alone or in conjunction with other medicines.
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Product description
Zestril — is an antihypertensive medication from the ACE group used to treat retinopathy or diabetic nephropathy, heart failure and arterial hypertension. Zestril contains Lisinopril. Lisinopril is categorically contraindicated in people with a particular susceptibility to Lisinopril and other ingredients of this drug, in lactation, pregnancy, aortic stenosis and angioedema. Only specialist can prescribe dosage and the course of treatment.
Indications
— arterial hypertension (in monotherapy or in combination with other antihypertensive agents); - chronic heart failure (as part of combined therapy for the treatment of patients taking digitalis and / or diuretics);
— early treatment of acute myocardial infarction (within the first 24 hours with stable hemodynamic parameters in order to maintain these parameters and to prevent the left ventricular dysfunction and heart failure);
- Diabetic nephropathy (decrease in albuminuria in insulin-dependent patients with normal blood pressure and in insulin-independent patients with hypertension)
Safety information
Directions
The drug is taken orally regardless of food intake regime. Patients with arterial hypertension who do not take other antihypertensives are prescribed 5 mg once a day. If there’s no effect, the dose is increased every 2-3 days by 5 mg to an average therapeutic dose of 20-40 mg / (increasing the dose above 40 mg usually does not lead to a further decrease in blood pressure). The usual daily maintenance dose is 20 mg. The maximum daily dose is 40 mg. The full effect usually develops in 2-4 weeks from the beginning of treatment, which should be taken into account when increasing the dose. It is possible to combine the drug with other antihypertensive drugs if clinical effect is insufficient.
Contraindications
— angioedema in anamnesis, also caused by use of ACE inhibitors;
— hereditary Quincke’s edema;
— age under 18 years (efficiency and safety are not determined);
— hypersensitivity to lisinopril or other ACE inhibitors;
– severe renal dysfunction, bilateral renal artery stenosis or arterial stenosis of a single kidney with progressive azotemia, a condition after kidney transplantation, renal failure, azotemia, hyperkalemia, aortic stenosis, hypertrophic obstructive cardiomyopathy, primary hyperaldosteronism, arterial hypotension, cerebrovascular diseases (including cerebral circulatory insufficiency),cardiac ischemia, coronary insufficiency, autoimmune systemic connective tissue diseases (including scleroderma, systemic lupus erythematosus); Oppression of bone marrow hematopoiesis; Diet with sodium restriction: hypovolemic conditions (including as a result of diarrhea, vomiting); elderly age.
Keep Zestril in a place inaccessible to children at a temperature of no higher than 30 ° C.
Side effects
The most common side effects: dizziness, headache (in 5-6% of patients), weakness, diarrhea, dry cough, nausea, vomiting, orthostatic hypotension, skin rash, chest pain.
On the level of immune system: angioedema (face, lips, tongue, larynx or epiglottis, upper and lower extremities).
On the level of cardiovascular system: severe decrease in blood pressure, orthostatic hypotension, renal insufficiency, heart rhythm disturbances, palpitations.
On the level of central nervous system: increased fatigue, drowsiness, convulsive twitching of the muscles of the extremities and lips.
On the level of the hematopoiesis system the following side effects are possible: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with long-term treatment - a slight decrease in the concentration of hemoglobin and hematocrit, erythrocytopenia.
Being a part of the medicine Allegra - fexofenadine it is an antihistamine with a selective antagonistic activity to H1-receptors without anticholinergic and blocking alfa1-adrenergic receptors; also at fexofenadine isn't observed a sedative action and other effects from the central nervous system. The antihistaminic effect of Allegra is observed in 1 hour, reaching its maximum in 6 hours, and proceeds within 24 hours. After 28 days of taking the medicine there wasn't observed the accustoming to it.
Brand Levitra – a drug from Bayer, with a basic chemical called Vardenafil, is an improved remedy for treating erectile difficulties. Operates approximately within 6-8 hours, so a man may be ready to perform sexually the whole night.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
Avapro - the remedy which is used separately or in combination with other drugs for treatment of high blood pressure. It is also used for treatment of diseases of kidneys caused by diabetes mellitus 2 type (the state at which the organism can't use insulin normally and, therefore, can't control amount of sugar in blood) and high blood pressure. Irbesartan in a class of the drugs called antagonists of receptors of angiotensin II. It works by blocking of effects of some natural substances which tighten blood vessels that allows blood flow more smoothly and the heart works more effectively.
Cozaar is used to treat arterial hypertension, protect the kidneys in type 2 diabetes mellitus with proteinuria, reduce the risk of associated cardiovascular diseases, as well as lower the death rate for hypertension, hypertrophy.
Endep - tricyclic antidepressant. The mechanism of antidepressive action is connected with increase in concentration of noradrenaline in synapses and/or serotonin in CNS (decrease in return absorption). Accumulation of these neurotransmitters results from inhibition of their return capture by membranes of presynaptic neurons.
Eulexin - antineoplastic medicine, anti-androgen. Competitively blocks interaction of androgens with their cellular receptors; interferes with manifestation of biological effects of male sex hormones in androgensensetive organs. It is taken for palliative treatment of cancer.
Famvir - antiviral medicine which is taken for prevention and treatment of herpes at primary infection, post-herpetic neuralgia, recurrent genital herpes. Pro-medicine; represents a 6-deoxysidiacetil analog of active antiviral agent of a penciclovir.
Keflex – It is used for the treatment of infections of the upper respiratory tract, urogenital system, ENT organs, skin and soft tissues, bones and joints. Refers to a group of cephalosporin antibiotics of the first generation. It has an bactericidal effect, disrupts the synthesis of the cell wall of microorganisms. It is resistant enough to penicillinases of gram-positive microorganisms, It can be destroyed by beta-lactamases of gram-negative microorganisms.
An antidepressant used in cases of deep depression, panic disorders, social anxiety disorders, anxiety disorders. The mechanism of its action is based on the ability to selectively block the reuptake of serotonin by the presynaptic membrane of the neurons of the brain. Consequently, its serotonergic effect in the central nervous system that is responsible for the development of antidepressant effect, increases, which determines the effectiveness in the treatment of panic and social anxiety disorder.
Mobic is a nonsteroidal anti-inflammatory drug, which has anti-inflammatory, antipyretic, analgesic effect. It belongs to the class of oxicams; derived from the anoliefo acid. Used in symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (Bekhterev's disease) and other inflammatory and degenerative diseases, accompanied by pain syndrome.
A blocker of H1-histamine receptors of the first generation, derived from ethanolamine; eliminates the effects of histamine, mediated through this type of receptors. Promotes the local anaesthesia (when intaken, there is a short numbing of the mucous membranes in the mouth) - only in high doses, it blocks m-cholinergic receptors in the central nervous system, has sedative, hypnotic, antiemetic and antiparkinsonian effects. The therapeutic indications include: allergic conjunctivitis, allergic rhinitis, chronic urticaria, pruritic dermatoses, dermatographism, serum sickness.
Prograf The active ingredient of the drug (Tacrolimus) binds to cytosolic protein (FKBP12), responsible for the intracellular accumulation of the drug. Designed for the prevention and treatment of allograft liver, kidneys and heart rejection reactions, including those resistant to standard immunosuppressive therapy regimes.
Vantin - combined preparation, based simultaneously on 2 active substances: Cefpodoxime Proxetil. It belongs to the third generation of cephalosporins. Used to treat acute otitis media, tonsilitis, pharyngitis, respiratory tract infections, such as pulmonary pneumonia and chronic bronchitis.
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
Sildenafil (ABHIGRA) 100 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
ERYC capsules contain enteric-coated pellets of erythromycin base for oral administration.
Erythromycin is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: