Lisinopril is an antihypertensive, vasodilating, cardioprotective drug, an ACE inhibitor that is used to treat hypertension, heart failure, acute myocardial infarction, diabetic nephropathy.
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Product Description
Lisinopril is used in various forms of arterial hypertension, including reninvascular heart failure (as part of complex therapy).Lisinopril is an ACE inhibitor that reduces the formation of angiotensin II from angiotensin I. Reducing angiotensin II it leads to a direct reduction in the release of aldosterone.Itreduces the degradation of Bradykinin and increases the synthesis of Pg.Itreduces OPSS, blood pressure, preload, pressure in the pulmonary capillaries, causes an increase in IOC and increased tolerance of the myocardium to the load in patients with CHF. It expands arteries more than veins.
Safety information
Mode of application
With arterial hypertension, the drug is prescribed in an initial dose of 10 mg once a day.If the hypotensive effect is insufficient, the dose of the drug is increased to 20-40 mg.In chronic heart failure, an initial dose of 2.5 mg;Maintenance dose - 5-20 mg.For patients with disturbed water-electrolyte metabolism, renal failure, renovascular hypertension, and also receiving diuretics, the initial dose of lisinopril is 2.5-5 mg.The medicine is taken once a day, regardless of food intake.
Contraindications
Hypersensitivity to lisinopril or other ACE inhibitors, pregnancy, lactation. Precautions.Angioedema in history against the background of ACE inhibitor therapy, hereditary or idiopathic angioedema, aortic stenosis, cerebrovascular disease, ischemic heart disease, coronary insufficiently,severe autoimmune systemic connective tissue disease (including lupus, scleroderma), inhibition of bone marrow hematopoiesis, diabetes Diabetes, hyperkalemia, bilateral renal artery stenosis, single kidney artery stenosis, condition after kidney transplantation, kidney failure, diet with Na + restriction, conditions accompanied by a decrease in BCC, elderly age, and age of 18 years.
Side effects
From the CCC: lowering blood pressure, arrhythmia, chest pain, rarely - orthostatic hypotension, tachycardia.On the part of the nervous system: dizziness, headache, fatigue, drowsiness, twitching of the muscles of the extremities and lips, rarely - asthenia, lability of mood, confusion.On the part of the digestive system: nausea, dyspepsia, decreased appetite, taste change, abdominal pain, diarrhea, dry mouth.From the hematopoiesis: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia.Allergic reactions: angioedema, skin rashes, itching.Laboratory indicators: hyperkalemia, hyperuricemia;Rarely - increased activity of "liver" transaminases, hyperbilirubinemia.Other: "dry" cough, decreased potency;Rarely - acute renal failure, arthralgia, myalgia, fever, edema, impaired renal fetal development.
Capoten suppresses activity of angiotensin-converting-enzyme therefore angiotensin-I turns into angiotensin II - substance which has strong vasoconstrictive action. Capoten reduces secretion of Aldosteronum in suprarenal cortex, at the same time the delay of sodium and water in an organism decreases. Capoten slows down process of bradykinin destruction and promotes increase of E2 prostaglandin, and also nitrogen oxide that causes vasodilating action. Thanks to these effects it is decreased the increased arterial pressure, the general peripheric resistance decreases, pressure in the right auricle, in a small circle of blood circulation decreases and cordial emission increases.
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The drug is an inhibitor of the enzyme peptidyl. It inhibits the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin I to vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates the secretion of aldosterone by the adrenal cortex. Inhibition of ACE leads to reduced concentrations of angiotensin II, resulting in low aldosterone secretion. The decrease in the latter leads to an increase in the content of potassium in the blood serum. Since the mechanism is believed to be based on the inhibition of the renin-angiotensin-aldosterone system, it reduces blood pressure even in patients with hypertension with low renin levels.
