Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
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The pills are a component of the group of antimetabolites with cytostatic activity. They reduce the change of dihydrofolic acid in tetrahydrofolic acid.
Product Description
There are changes in Timpilo acid and purine, which in turn changes the connection of DNA and division of cells, the connection of RNA and protein. The peculiarity of the drug is in the s-phase of the cell cycle. The most sensitive to the drug are tissues with high proliferative potential (tumor tissue, bone marrow, epithelial cells, and fetal cells).
After 30 to 60 minutes, administration to the muscle has the highest concentration. The drug is well dispersed in body tissues, as well as in ascitic and pleural fluids. The kidney tissue is determined in several weeks and the tissues of the liver, for three months. When the pills are used in medium amounts, they do not penetrate the blood-brain barrier. It is metabolized by enzymes of the intestinal microflora, hepatocytes and other cells with the formation of active metabolite – pollutant (inhibitor of dihydrofolate reductase and timdelaghetto).
The terminal half-life time is dose-dependent and lasts from three to ten hours and eight to fifteen hours when using small and large doses of the drug. 90% of the received dose comes out with urine in its present form by glomerular filtration and active tubular secretion and only ten percent – within 24 hours with bile (followed by reabsorption in the intestine).
The components mostly come out with urine and its characteristics do not change. When the activity of kidney function is impaired, the elimination of methotrexate decreases speed, while its concentration in the blood plasma increases. The components could be released into breast milk.
Safety information
The pills cannot be combined with strong oxidants and acids. If they are mixed with chlorpromazine hydrochloride, droperidol, metoclopramide hydrochloride, heparin solution, prednisolone sodium phosphate and hydrochloride promethazine it would be possible to obtain its turbidity or precipitate formation.
The amount is calculated according to the weight of the person or the surface area of the skin. The tablets are effective in case of a large number of cancers as a monotherapy, and in combination with other chemotherapy drugs.
Side Effects
The pills have a negative impact on the blood system: it inhibits bone marrow function (as a result it leads to infection, sepsis, bleeding), thrombocytopenia, leukopenia, anemia, and hematoma. In the digestive system, there are such problems as gingivitis, stomatitis, pharyngitis, nausea may appear, and the patient often goes to the toilet experiencing stomach disorders. Sometimes people taking this drug feel a violation of liver function. There a liver dystrophy, erosive and ulcerative disorders of the mucous membrane of the stomach and intestines, and a liver failure may happen.
As for disorders in the nervous system, a person has a headache, dizziness, vision impairment, hemiparesis, seizures. After intrathecal administration, the pressure of cerebrospinal fluid increases. In the genitourinary system: a person starts to suffer from cystitis, azotemia, hematuria, women have the menstrual disorder, infertility, vaginal, spontaneous abortion, teratogenic effect, decreased libido, impotence, ovogenesis, spermatogenesis. Pills can lead to negative consequences of the skin such as rash, skin can itch, acne, furunculosis develops. Sometimes there is a Stevens-Johnson syndrome.
Cephalexin - antibacterial agents for systemic use. Cephalosporins of the first generation. Used in the treatment of infections caused by microorganisms susceptible to cefalexin: ENT organs and respiratory tract, genitourinary system, skin and soft tissues, bone tissue and joints.
Viagra Professional - Advantage of Professional Viagra from usual Viagra is that it works twice longer (6 - 8 hours) and has a stronger effect. Strengthens desire, improves brightness of sexual feelings and increases duration of sexual intercourse.
Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.
Cordarone - antiarrhytmic drug of III class (repolarization inhibitor). Possesses also anti-anginal, coronarodilator, alpha and beta, adrenoceptor blocking and hypotensive action. The anti-anginal effect of Cordarone is caused by coronarodilator and anti-adrenergic action, reduction of need of a myocardium for oxygen.
is given to patients for treating severe acne that do not respond to other medicines
Exforge the combined antihypertensive which includes amlodipine and valastran. Valsartan - a specific blocker of AT1 receptors of angiotensin II. Amlodipin - calcium channel blocking agents of III generation, inhibits transmembrane receipt of Ca2+ in cardiomyocytes and smooth muscle cells of vessels, by weakening them.
Levitra Soft - convenient chewable tablets, also act as their famous analogue - Brand Levitra, but cost several times cheaper. This form of generic tablet has a pleasant taste, it does not need to be taken with water. The effect occurs maximum in 15 minutes after taking the drug and lasts about 12 hours. The tablet can be combined with alcohol and fatty foods. The number of side effects is minimal and they are manifested only in cases of an overdose.
An inhibitor of proton pump. The drug indications include: gastric ulcer and duodenal ulcer (in an acute phase), erosive gastritis, reflux-esophagit, Zolling-Erellison syndrome.
Viagra Soft Flavored - chewing tablet viagra, which has a mint taste and differs from usual viagra by mode of administration and speed of effect. Unlike usual viagra - Viagra Soft Flavored should be resolved or chewed. So at administration of drug it is possible to take alcohol and greasy food that is not recommended at taking of any other type of viagra. The effect of Viagra Soft Flavored comes in 30 minutes after reception, and lasts for 4 hours.
is given to patients for treating severe acne that do not respond to other medicines
Avalide is an effective medicine which aim is to lower the blood pressure. Hypertension provokes serious diseases as strokes, heart attack, and problems with the kidney. An angiotensin receptor blocker and diuretic are the basic components of the drug. The first one relaxes the walls of the blood vessels letting the blood move freely without the pressure. The second component stimulates urination so that a patient can get rid of extra salt and water which also provoke high blood pressure.
Dostinex is used to treat hyperprolactinemia, which manifests as infertility, a violation of the menstrual cycle (oligomenorrhea, amenorrhea, anovulatory menstrual cycles), galactorrhea in women. Men use it to treat hyperprolactinemia, which manifests itself by a decrease in libido or impotence. The drug copes with micro- or macroprolactinoma, idiopathic hyperprolactinemia, syndrome of an empty Turkish saddle. It also suppresses physiological lactation after childbirth if the woman is unwilling or unable to breastfeed, or if there are contraindications to feeding for the child or the mother. The drug prevents lactation after childbirth in case of abortion or stillbirth.
This product is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains 2 medications: clonidine and chlorthalidone.
Elocon (mometasone furoate) Cream, 0.1% is a corticosteroid topical cream, lotion, or ointment indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 2 years of age or older.
