Prednisolone is a synthetic analogue of the adrenal cortex secreted by the hormones cortisone and hydrocortisone. Unlike cortisone and hydrocortisone, prednisolone does not cause a noticeable delay in sodium and water, and only slightly increases the release of potassium. The drug has a pronounced anti-inflammatory, antiallergic, anti exudative, anti-shock, antitoxic effect.
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Product description
Prednisolone is a synthetic analogue of the adrenal cortex secreted by the hormones cortisone and hydrocortisone. Prednisolone is 4-5 times more active than cortisone and 3-4 times as compared with hydrocortisone when administered orally. Unlike cortisone and hydrocortisone, prednisolone does not cause a noticeable delay in sodium and water, and only slightly increases the release of potassium. The drug has a pronounced anti-inflammatory, antiallergic, antiexudative, anti-shock, antitoxic effect.
Indications
- Collagenosis, rheumatism, infectious nonspecific polyarthritis (inflammation of several joints), bronchial asthma, acute lymphoblastic and myeloblastic leukemia (malignant blood tumor originating from the blood-forming bone marrow cells), infectious mononucleosis;
- An acute infectious disease that occurs with a high temperature rise, an increase in palatine lymph nodes, a liver), neurodermatitis (skin disease due to impairment of the central nervous system), eczema (a neuro-allergic skin disease characterized by dizzying, itchy inflammation) and other skin diseases, various allergic diseases, Addison's disease (decreased adrenal function), acute adrenocortical insufficiency, hemolytic anemia (decrease in hemoglobin in the blood due to increased erythrocyte decay), glomerulonephritis (kidney disease), acute pancreatitis (inflammation of the pancreas);
- To prevent shock and collapse (a sharp drop in blood pressure) during surgical interventions;
- To suppress the rejection reaction in homotransplantation (transplantation from one person to another) organs and tissues;
- Allergic, chronic and atypical conjunctivitis (inflammation of the outer shell of the eye) and blepharitis (inflammation of the eyelid edges); Inflammation of the cornea with intact mucosa;
- Acute and chronic inflammation of the anterior segment of the choroid, sclera (opaque part of the fibrous membrane of the eyeball) and episcleras (the outer loose layer of the sclera, in which the blood vessels pass);
- Sympathetic inflammation of the eyeball (inflammation of the anterior part of the choroid of the eye due to penetrating injury of the other eye);
- After injuries and operations with prolonged irritation of eyeballs.
- Severe forms of hypertension (persistent rise in blood pressure),
- diabetes mellitus and Itenko-Cushing's disease;
- Pregnancy, circulatory failure III stage,
- acute endocarditis (inflammation of the internal cavities of the heart),
- psychosis,
- nephritis (inflammation of the kidneys),
- osteoporosis,
- peptic ulcer of the stomach and duodenum,
- recent surgery,
- syphilis,
- active tuberculosis,
- senile age.
- obesity,
- hirsutism (excessive hair in women, manifested by the growth of beard, mustache, etc.),
- the appearance of acne,
- menstrual irregularity,
- osteoporosis,
- the symptom complex of Itenko-Cushing (obesity, accompanied by a decrease in sexual function, increased fragility of the bones due to Increased ulceration of the adrenocorticotropic hormone of the pituitary gland),
- ulceration of the digestive tract,
- perforation of the unrecognized ulcer (the appearance of a through wall or gut wall defect at the site of the ulcer),
- hemorrhagic pancreatitis (inflammation of the pancreas flowing with a hemorrhage into her body),
- hyperglycemia (increase of blood sugar level),
- a decrease in resistance to infections,
- increased coagulability of blood,
The dose is set individually.
Safety information
Contrindications
During pregnancy, especially in the first trimester, prednisolone should be administered with an extreme caution.
Side effects
In case of prolonged use:
- obesity,
- hirsutism (excessive hair in women, manifested by the growth of beard, mustache, etc.),
- the appearance of acne,
- menstrual irregularity,
- osteoporosis,
- the symptom complex of Itenko-Cushing (obesity, accompanied by a decrease in sexual function, increased fragility of the bones due to Increased ulceration of the adrenocorticotropic hormone of the pituitary gland),
- ulceration of the digestive tract,
- perforation of the unrecognized ulcer (the appearance of a through wall or gut wall defect at the site of the ulcer),
- hemorrhagic pancreatitis (inflammation of the pancreas flowing with a hemorrhage into her body),
- hyperglycemia (increase of blood sugar level),
- a decrease in resistance to infections,
- increased coagulability of blood, mental disorders.
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