Differin is a white gel or cream. The drug is used to treat acne. It can also be used to combat comedones. Differin monotherapy is helpful in case of minor acne. For the treatment of severe and moderate degree of acne, the drug is used in conjunction with systemic drugs (antiandrogens, antibacterial agents). The drug is well tolerated. It rarely causes irritation, so its use is good even for those who have sensitive skin with acne. The gel is more suitable for oily skin and the cream suits better for dry skin.
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Product description
Differin belongs to the category of topical retinoids aimed at the treatment of acne vulgaris that occurs in young people starting from 12 years of age. The name Acne vulgaris indicates the condition of the face, back or chest characterized by the presence of blackheads, whiteheads, and pimples. Surveys show that at least 85% of the US entire population is affected by acne at a certain point in their life.
The active substance of Differin is Adapalene that works due to its properties of a vitamin A derivative. It binds to nuclear receptors that are specific for retinoic acids. At the same time, it avoids binding to the cytosolic receptor protein. This selectivity allows adapalene to modulate the processes of keratinization, inflammation development, and cellular differentiation.
The Nonprescription Drugs Advisory Committee by FDA has confirmed that the pharmacological safety profile and the application data amassed for adapalene gel 0.01% are sufficient to make the product available over-the-counter.
Directions for use
Differin Gel 1mg/g should be applied as follows:
- Clean the acne-affected skin using a mild lotion or a soap.
- Rinse carefully and dry with easy movements.
- Spread Differin gel thinly to the affected areas. Apply it to both the pimples and surrounding skin. Leave the gel for a minute to dry.
- Do not remove or wash the gel from your face after application. Avoid touching or rubbing the treated areas.
Try not to use oil-based cosmetics and ointments. Makeup products providing a drying, abrasive, or peeling effect may lead to additional irritation of the skin.
Safety information
Patients should bring sunlight exposure to the minimum, including solarium lamps and sunlamps, during the treatment with Differin. If it is not possible to avoid the exposure, use sunscreens and protective clothing. Extreme wind or cold temperatures may also cause irritation.
Differing should not come in contact with the lips, wings of the nose, eyes, and mucous membranes. Avoid applying the medicine on cuts, scratches, patches of skin damaged by eczema or sunburns. Similarly to all retinoids, adapalene is not compatible with skin waxing.
Caution should be observed when combining Differin with other topical-action products, such as medicated soaps or cleansers with abrasive effect, as well as alcohol-containing products or astringents. Use with extra care any preparation comprising resorcinol, sulfur, or salicylic acid when staying with Differin.
This medicine has an unknown potential for use in pregnant women or those planning pregnancy. The data by FDA shows that about 12% of adult American women suffer from moderate to severe acne. The study comparing the safety risk against the pharmaceutical’s beneficial potential in animals has confirmed adapalene to be teratogenic and malformation-inducing when given orally at high dose levels (25 mg/kg and 60 mg/kg).
Side effects
In placebo-controlled clinical studies, use of Differin was most commonly associated (≥1%) with skin dryness, irritation and discomfort, itchy feelings, skin desquamation, and painful sunburns.
The above are mild reactions and they normally pass quickly. However, you should not postpone your visit to the doctor if you notice or are bothered by any of the following adverse effects: contact dermatitis/eczema-like manifestations, acne flare, facial swelling, acute conjunctivitis.
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Cephalexin - antibacterial agents for systemic use. Cephalosporins of the first generation. Used in the treatment of infections caused by microorganisms susceptible to cefalexin: ENT organs and respiratory tract, genitourinary system, skin and soft tissues, bone tissue and joints.
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is given to patients for treating severe acne that do not respond to other medicines
Exforge the combined antihypertensive which includes amlodipine and valastran. Valsartan - a specific blocker of AT1 receptors of angiotensin II. Amlodipin - calcium channel blocking agents of III generation, inhibits transmembrane receipt of Ca2+ in cardiomyocytes and smooth muscle cells of vessels, by weakening them.
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Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
Viagra Soft Flavored - chewing tablet viagra, which has a mint taste and differs from usual viagra by mode of administration and speed of effect. Unlike usual viagra - Viagra Soft Flavored should be resolved or chewed. So at administration of drug it is possible to take alcohol and greasy food that is not recommended at taking of any other type of viagra. The effect of Viagra Soft Flavored comes in 30 minutes after reception, and lasts for 4 hours.
is given to patients for treating severe acne that do not respond to other medicines
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Elocon (mometasone furoate) Cream, 0.1% is a corticosteroid topical cream, lotion, or ointment indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 2 years of age or older.
