Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.

Calcium channel blocker, a derivative of 1,4-dihydropyridine, has a predominantly cerebrovasculative and antiischemic action. Prescribed for the prevention and treatment of brain ischemia on the background of subarachnoid hemorrhage caused by aneurysm rupture, expressed by brain disfunction in the elderly patients. It can prevent or eliminate spasm of vessels caused by various vasoconstrictor drugs. Improves stability and functional capacity of neurons.